NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in every cell of the body, essential for energy metabolism, DNA repair, and cellular signaling. NAD+ levels naturally decline by 40–60% between ages 20 and 60, and this decline is strongly associated with hallmarks of aging.
NAD+ is a cofactor for over 500 enzymatic reactions, including those performed by sirtuins (the "longevity genes") and PARPs (DNA repair enzymes). Restoring NAD+ levels activates these pathways, supporting mitochondrial function, reducing oxidative stress, and potentially slowing cellular aging processes.
IV NAD+ therapy is reported to produce rapid boosts in energy and mental clarity. Subcutaneous NAD+ precursor therapy shows more gradual but sustained improvements in energy, cognitive function, and overall vitality over weeks to months.